Does chronic kidney decline what is the manage of hair interpretation of the cause of intercurrent anaemia?
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CRF patient all accompanies the anaemia that has different rate, and as kidney function drop, anaemia accentuates gradually. The manage of hair interpretation of the cause with intercurrent and anaemic CRF has the following sides: (1) red blood cell generates decrease: ① red blood cell generates element to decrease: Red blood cell makes element main by kidney spherule close ball cell, medullary a qualitative cell generation. When CRF, outside the place damage that makes element besides nephritic generation red blood cell, haemoglobin is reduced to the affinity of oxygen, unit haemoglobin increases to the utilization rate of oxygen, the kidney is short of blood relatively lax heavy, the main stimulation that produces red blood cell to make element decreases, the generation that brings about red blood cell to make element decreases apparently. ② toxin restrains marrow: The certain noxiousness material of the save up in the blood when CRF has direct inhibition to marrow, pose hematopoiesis function obstacle. Obstacle of ③ iron motivation: The keep in storage of iron and function of metabolization of meshy endodermis system are unusual, of the iron that haemoglobin metabolization comes out release be affected, its are serum iron drops and the iron of supply marrow decreases as a result, influence hematopoiesis. ④ folic acid lacks: As a result of intake inadequacy often causes folic acid shortage when CRF. In addition, uremic patient folic acid combines albumen to estimate increase, can make move decreases to the folic acid amount inside the cell. Long-term and dialytic patient produces folic acid more easily to lack. (2) red blood cell destroys grow in quantity: The reason includes: Disease of blood of tall much amine causes loss of life of red blood cell when uremia, happen from dissolve; Obstacle of metabolization of the red blood cell when uremia and brittleness of red blood cell increase, cause red blood cell from dissolve; Capillary pathological changes makes red blood cell gets damage and destroy; Lienal function hyperfunction. (3) red blood cell is missing increase: Go up for a long time chronically enteron or next enteron are recessive haemorrhage, the lab often remains in exsanguinate assay or dialyzer hematic loss, can accentuate anaemic.
